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KMID : 0613820070170060873
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Journal of Life Science
2007 Volume.17 No. 6 p.873 ~ p.875
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The inhibitory effect on the melanin synthesis in B16/F10 mouse melanoma cells by Sasa quelpaertensis leaf extract
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Yoon Hoon-Seok
Kim Jeong-Kook
Kim Se-Jae
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Abstract
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Effects of hot-water extract from Sasa quelpaertensis leaf (HWES) on melanogenesis were investigated in B16/F10 mouse melanoma cells. HWES inhibited cellular tyrosinase activity and melanin biosynthesis in a dose-dependent manner. Western blotting analysis showed that HWES dose-dependently inhibited tyrosinase and tyrosinase related protein-1 expression. Also, HWES suppressed sustained ERK activation in a concentration-dependent manner, suggesting that HWES inhibits the melanin biosynthesis through the suppressive effect against pathway involving sustained ERK activation.
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KEYWORD
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Sasa quelpaertensis, tyrosinase, melanogenesis, sustained ERK activation
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